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HGH / Somatropin

Protein / hormone · Endocrine signals

Replaces growth hormone in diagnosed deficiency; approved products are prescription-only and limited to defined indications.

Approved for specific usesWADA
LibraryNo account · this device only

Also known as: HGH · Human growth hormone · Somatropin

Use at a glance

HGH / Somatropin

Replaces growth hormone in diagnosed deficiency; approved products are prescription-only and limited to defined indications.

Which entry would you like to view?

Choose a source entry. Different products and study groups do not form one combined plan.

Medicine instructions · named product only

Product or source: HGH / Somatropin · GENOTROPIN / NORDITROPIN

What amount?
0.15–0.30 mg
How often?
once per day
What time of day?
Time of day not stated here
In what setting?
Adult GHD · entry
How is it used?
Different products or dosage forms exist. First check the full product name and form on the packaging.
Does it need mixing?
It depends on the exact form. Do not dilute a ready-made solution yourself; use a powder's specific instructions.
View preparationCheck sources
Overview of all entries

  • HGH / Somatropin · Adult GHD · entry

    Medicine instructions · named product only · GENOTROPIN / NORDITROPIN

    0.15–0.30 mg · once per day · Time of day not stated here

  • HGH / Somatropin · Adult GHD · titration

    Medicine instructions · named product only · GENOTROPIN / NORDITROPIN

    +0.1–0.2 mg · every 1–2 months · Time of day not stated here

  • HGH / Somatropin · Adult GHD · weight-based

    Medicine instructions · named product only · GENOTROPIN

    ≤0.04 → ≤0.08 mg/kg/W · 4–8 weeks / per step · Time of day not stated here

More factsProtein / hormone · Endocrine signals
Classification
Protein / hormone · Endocrine signals
Research focus
Replaces growth hormone in diagnosed deficiency; approved products are prescription-only and limited to defined indications.
Evidence
Established
Status
Approved for specific uses

Approved uses exist, but dose, formulation, device and monitoring are product- and indication-specific. A community table cannot replace the prescribing information or a prescription.

Schedule explained in detailApproved medicine

Amount status

There is no generic somatropin dose. It depends on the product, approved indication, age, weight, IGF-1 and clinical response.

Profile evidence level: established.

Timing

Timing and delivery system are product-specific; pens, cartridges and vials are not interchangeable.

No individual recommendation.

Cycle/duration

Treatment and dose adjustment happen long-term under specialist medical supervision, not as a bodybuilding or anti-aging cycle.

No individual recommendation.

Mixing & calculations

It depends on the exact form. Do not dilute a ready-made solution yourself; use a powder's specific instructions.

All preparation informationProduct details and calculation examples from the available sources.

Reconstitute exclusively per the prescribing information of the exact somatropin product and with its intended diluent/device. A generic U-100 calculator is not suitable for this.

Reconstitution & quantitiesOpen basics, units and sources
Explained in very simple termsBefore reading any number: this page reports what a product label, study or online community states. It does not say what any person should use.

Amount

mg or µg describe the mass of a substance. That is not the same as ml of fluid or U on a syringe. The number is only the amount stated by the identified source.

Interval

The interval only describes the time stated between two points. For example, once every 7 days does not mean daily and never justifies catching up or doubling.

Cycle

A cycle is a stated period that may include breaks. A community cycle proves neither effectiveness nor safety and does not prevent long-term risks.

Reconstitution

Reconstitution means mixing powder with a defined volume of fluid. This changes concentration, not the total amount in the vial. On U-100, 100 U equals exactly 1 ml of volume.

Not a guide to misuse

All community figures are shown only to place widely circulated online protocols in context. They are not instructions for self-use, injection, performance enhancement or any other misuse. Approved figures apply only to the exact named product, approved indication and medical supervision.

Research, risks & more detailsMechanism, adverse effects, storage, comparisons and common questions.

Mechanism: what is supported and what does not follow

Recombinant human growth hormone acting at the growth-hormone receptor

HGH / Somatropin is classified as “Recombinant human growth hormone acting at the growth-hormone receptor”. Replaces growth hormone in diagnosed deficiency; approved products are prescription-only and limited to defined indications. This describes the investigated pathway but does not validate a community use, amount, route or combination.

01

HGH replacement therapy

This studies direct administration of recombinant growth hormone for a confirmed deficiency, similar to replacing a missing substance the body normally produces. Growth, body composition, and hormone levels are measured in clinical studies.

02

Growth-axis amplification

Researchers study how a substance amplifies the natural hormone chain from brain to pituitary to growth hormone, rather than supplying growth hormone directly. Hormone levels over time and muscle or fat mass are measured.

03

IGF-1 splice variant

This studies how a locally produced tissue variant of the growth factor IGF-1 might be involved in muscle cell repair, similar to a regional rather than a body-wide response. Cell growth and repair markers are measured in lab models.

What communities discuss

These themes describe discussions and vendor claims. They do not prove benefit, safety, product identity or suitable use.

Bodybuilding forums

Here, muscle growth, strength gains, and recovery times are compared between different growth and repair peptides, often based on personal training logs. Vendor and user claims about muscle gains are anecdotal experience, not controlled study results.

Anti-aging forums

Combinations of growth-axis, mitochondrial, and skin peptides are compared here with the goal of influencing visible or felt signs of ageing, often documented personally over years. Anecdotes and vendor advertising about slowed ageing are not scientific proof.

Source and purity discussion

Discussion covers which vendors are seen as more trustworthy and how purity test results differ between batches. Such community assessments are based on limited samples and do not replace independent lab testing of each individual batch.

Adverse effects and safety risks

  • Interference with GH, IGF-1 or other hormone axes may cause oedema, joint or nerve symptoms, glucose intolerance, blood-pressure and hormonal changes; dependable human data are absent for many research substances.
  • Local reaction, infection, abscess and contamination are possible with any injection that is not professionally manufactured and administered.
  • A label or clear appearance does not exclude unknown purity, wrong identity, endotoxins or concentration errors.

Do not self-use / obtain clinical review

  • Active or previous malignancy, uncontrolled diabetes, intracranial disease, pregnancy/breastfeeding and hormone-sensitive disease require specialist assessment; approved products have specific contraindications.
  • Acute symptoms, allergic reaction, breathing difficulty, chest pain, neurological deficits or severe abdominal pain require immediate medical care.
  • Children and adolescents, pregnancy/breastfeeding, and people with relevant disease should not be part of unsupervised experiments.

Monitoring and laboratory markers

  • In medically justified use, IGF-1, fasting glucose/HbA1c, blood pressure, weight/oedema, thyroid and indication-specific hormones may be relevant; this is not a self-testing schedule.
  • Baseline, objective, measurement timing and stop criteria must be defined professionally in advance. Individual laboratory values cannot compensate for unknown product quality.

Evidence boundary

Established

Approved products are prescription-only and limited to defined deficiency conditions.

Clinical evidence

The described biological role is well established, or extensive regulator-reviewed human data exist for clearly defined products and uses. This does not automatically transfer to other products or purposes.

Somatropin is recombinant growth hormone itself, whereas secretagogues like sermorelin only stimulate the body's own release.

Storage and stability

  • The manufacturer label and prescribing information take priority. Storage instructions from a different product do not transfer.
  • Unapproved vials often lack dependable stability data before and after mixing; ‘2–8 °C’ or ‘28 days’ is not a universal standard.
  • Do not use after seal damage, particles, cloudiness, discoloration, unknown date or interrupted cold chain. Visual inspection does not prove sterility.

Troubleshooting and common errors

  • U-100 units measure volume, not drug amount: 100 U equals 1 mL. A wrong concentration makes every unit figure wrong.
  • Do not shake or dilute further to ‘fix’ cloudiness, particles or uncertain solubility; discard and obtain professional clarification.
  • Do not calculate a double or extra amount to compensate for missed use or an uncertain injection.
  • Without a COA, clear supplier, correct label and consistent vial information, identity is not confirmed.

Regulatory status and WADA

Approved for specific uses

Prescription active ingredient for defined indications in at least one jurisdiction; not offered here.

WADA 2026

This profile is marked as WADA-relevant. Check the current Prohibited List and the specific sport or route in the original; a prohibition may cover an entire class or related agents.

WADA — 2026 Prohibited List

Combinations / stacks

  • Combinations change effects, adverse effects and laboratory values; evidence for one substance does not establish the safety of a stack.
  • Overlapping pathways may add up. Hormonal, glucose, blood-pressure, coagulation, immune and sedating effects are important potential interactions.
  • Non-standardised blends prevent separate dosing, cause attribution and dependable reconstitution.

Frequently asked questions

Is an amount shown here a recommendation?

No. This page separates approved product information, study protocols and community information. No number or calculator is an individual dosing recommendation.

Does the U-100 calculator prove correct use?

No. It only converts mass, volume and syringe scale. It cannot check identity, purity, sterility, stability, solvent or medical suitability.

Can this profile be combined with other substances?

Safety of a combination cannot be inferred from a single-substance profile. Overlapping pathways, medicines and undefined blends can increase risk.

Which source controls when information conflicts?

For approved medicines, the current prescribing information and treating professional control. For research substances, conflict shows that no dependable self-use standard exists.

Are community claims clinical evidence?

No. Anecdotes can generate questions but do not replace controlled studies, regulatory review, or identity and quality testing.

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